Publications (Conradt)

Sethi, A., Wei, H., Mishra, N., Segos, I., Lambie, E. J., Zanin, E., & Conradt, B. (2022). A caspase-RhoGEF axis contributes to the cell size threshold for apoptotic death in developing Caenorhabditis elegans. PLoS Biology, 20 (10), e3001786. doi:10.1371/journal.pbio.3001786
Rolland, S., & Conradt, B. (2022). Genetic screen identifies non-mitochondrial proteins involved in the maintenance of mitochondrial homeostasis. microPublication Biology. doi:10.17912/micropub.biology.000562
Haeussler, S., & Conradt, B. (2022). Methods to Study the Mitochondrial Unfolded Protein Response (UPRmt) in Caenorhabditis elegans. Methods in Molecular Biology, 2378, 249-259. doi:10.1007/978-1-0716-1732-8_16
Haeussler, S., Yeroslaviz, A., Rolland, S. G., Luehr, S., Lambie, E. J., & Conradt, B. (2021). Genome-wide RNAi screen for regulators of UPRmt in Caenorhabditis elegans mutants with defects in mitochondrial fusion. G3 (Bethesda). doi:10.1093/g3journal/jkab095
Haeussler, S., Köhler, F., Witting, M., Premm, M. F., Rolland, S. G., Fischer, C., . . . Conradt, B. (2020). Autophagy compensates for defects in mitochondrial dynamics. PLoS Genet, 16 (3), e1008638. doi:10.1371/journal.pgen.1008638
Fischer, C. A., Besora-Casals, L., Rolland, S. G., Haeussler, S., Singh, K., Duchen, M., . . . Marr, C. (2020). MitoSegNet: Easy-to-use Deep Learning Segmentation for Analyzing Mitochondrial Morphology. iScience, 23 (10). doi:10.1016/j.isci.2020.101601
Basch, M., Wagner, M., Rolland, S., Carbonell, A., Zeng, R., Khosravi, S., . . . Wagener, N. (2020). Msp1 cooperates with the proteasome for extraction of arrested mitochondrial import intermediates. Molecular biology of the cell, 31 (8), 753-767. doi:10.1091/mbc.E19-06-0329
Wei, H., Lambie, E. J., Osório, D. S., Carvalho, A. X., & Conradt, B. (2020). PIG-1 MELK-dependent phosphorylation of nonmuscle myosin II promotes apoptosis through CES-1 Snail partitioning. PLoS Genet, 16 (9), e1008912. doi:10.1371/journal.pgen.1008912
Deng, W., Bates, J. A., Wei, H., Bartoschek, M. D., Conradt, B., & Leonhardt, H. (2020). Tunable light and drug induced depletion of target proteins. Nature Communications, 11 (1). doi:10.1038/s41467-019-14160-8
Rolland, S. G., Schneid, S., Schwarz, M., Rackles, E., Fischer, C., Haeussler, S., . . . Conradt, B. (2019). Compromised Mitochondrial Protein Import Acts as a Signal for UPRmt. Cell Reports. doi:10.1016/j.celrep.2019.07.049
Wei, H., Yan, B., Gagneur, J., & Conradt, B. (2019). Corrigendum: Caenorhabditis elegans CES-1 Snail Represses pig-1 MELK Expression To Control Asymmetric Cell Division. Genetics, 211 (2), 787. doi:10.1534/genetics.118.301849
Wagner, A., Hofmeister, O., Rolland, S. G., Maiser, A., Aasumets, K., Schmitt, S., . . . Wolf, A. (2019). Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans. Journal of Cell Science, 132 (19). doi:10.1242/jcs.223891
Erpf, A. C., Stenzel, L., Memar, N., Antoniolli, M., Osepashvili, M., Schnabel, R., . . . Mikeladze-Dvali, T. (2019). PCMD-1 Organizes Centrosome Matrix Assembly in C. elegans. Current Biology, 29 (8), 1324-1336.e6. doi:10.1016/j.cub.2019.03.029
Conradt, B. (2019). The Power of C. elegans: A Tribute to Sydney Brenner – A Spirit of Innovation. DEVELOPMENTAL CELL, 49 (4), 496. doi:10.1016/j.devcel.2019.05.009
Memar, N., Schiemann, S., Hennig, C., Findeis, D., Conradt, B., & Schnabel, R. (2019). Twenty million years of evolution: The embryogenesis of four Caenorhabditis species are indistinguishable despite extensive genome divergence. Developmental Biology. doi:10.1016/j.ydbio.2018.12.022
Mishra, N., Wei, H., & Conradt, B. (2018). Caenorhabditis elegans ced-3 Caspase Is Required for Asymmetric Divisions That Generate Cells Programmed To Die. GENETICS, 210 (3), 983-998. doi:10.1534/genetics.118.301500
Zielich, J., Tzima, E., Schröder, E. A., Jemel, F., Conradt, B., & Lambie, E. J. (2018). Overlapping expression patterns and functions of three paralogous P5B ATPases in Caenorhabditis elegans. PLoS ONE, 13 (3), e0194451. doi:10.1371/journal.pone.0194451
Wei, H., Yan, B., Gagneur, J., & Conradt, B. (2017). Caenorhabditis elegans CES-1 Snail Represses pig-1 MELK Expression To Control Asymmetric Cell Division. GENETICS, 206 (4), 2069-2084. doi:10.1534/genetics.117.202754
Sherrard, R., Luehr, S., Holzkamp, H., McJunkin, K., Memar, N., & Conradt, B. (2017). miRNAs cooperate in apoptosis regulation during C. elegans development. GENES & DEVELOPMENT, 31 (2), 209-222. doi:10.1101/gad.288555.116
Conradt, B. (2017). Partners in Crime. DEVELOPMENTAL CELL, 41 (6), 573-574. doi:10.1016/j.devcel.2017.06.002
Lambie, E. J., & Conradt, B. (2016). Deadly dowry: how engulfment pathways promote cell killing. CELL DEATH AND DIFFERENTIATION, 23 (4), 553-554. doi:10.1038/cdd.2015.170
Conradt, B., Wu, Y. -. C., & Xue, D. (2016). Programmed Cell Death During Caenorhabditis elegans Development. GENETICS, 203 (4), 1533-1562. doi:10.1534/genetics.115.186247
Chakraborty, S., Lambie, E. J., Bindu, S., Mikeladze-Dvali, T., & Conradt, B. (2015). Engulfment pathways promote programmed cell death by enhancing the unequal segregation of apoptotic potential. NATURE COMMUNICATIONS, 6, ARTN 10126. doi:10.1038/ncomms10126
Koehler, F., Mueller-Rischart, A. K., Conradt, B., & Rolland, S. G. (2015). The loss of LRPPRC function induces the mitochondrial unfolded protein response. AGING-US, 7 (9), 701-717.
Roy, S. H., Tobin, D. V., Memar, N., Beltz, E., Holmen, J., Clayton, J. E., . . . Saito, R. M. (2014). A Complex Regulatory Network Coordinating Cell Cycles During C. elegans Development Is Revealed by a Genome-Wide RNAi Screen. G3-GENES GENOMES GENETICS, 4 (5), 795-804. doi:10.1534/g3.114.010546
Regmi, S. G., Rolland, S. G., & Conradt, B. (2014). Age-dependent changes in mitochondrial morphology and volume are not predictors of lifespan. AGING-US, 6 (2), 118-130. doi:10.18632/aging.100639
Ye, A. L., Ragle, J. M., Conradt, B., & Bhalla, N. (2014). Differential Regulation of Germline Apoptosis in Response to Meiotic Checkpoint Activation. GENETICS, 198 (3), 995-1000. doi:10.1534/genetics.114.170241
Zanin, E., Desai, A., Poser, I., Toyoda, Y., Andree, C., Moebius, C., . . . Oegema, K. (2013). A Conserved RhoGAP Limits M Phase Contractility and Coordinates with Microtubule Asters to Confine RhoA during Cytokinesis. DEVELOPMENTAL CELL, 26 (5), 496-510. doi:10.1016/j.devcel.2013.08.005
Lambie, E. J., Tieu, P. J., Lebedeva, N., Church, D. L., & Conradt, B. (2013). CATP-6, a C. elegans Ortholog of ATP13A2 PARK9, Positively Regulates GEM-1, an SLC16A Transporter. PLOS ONE, 8 (10), ARTN e77202. doi:10.1371/journal.pone.0077202
Yan, B., Memar, N., Gallinger, J., & Conradt, B. (2013). Coordination of Cell Proliferation and Cell Fate Determination by CES-1 Snail. PLOS GENETICS, 9 (10), ARTN e1003884. doi:10.1371/journal.pgen.1003884
Rolland, S. G., Motori, E., Memar, N., Hench, J., Frank, S., Winklhofer, K. F., & Conradt, B. (2013). Impaired complex IV activity in response to loss of LRPPRC function can be compensated by mitochondrial hyperfusion. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110 (32), E2967-E2976. doi:10.1073/pnas.1303872110
Shen, Q., He, B., Lu, N., Conradt, B., Grant, B. D., & Zhou, Z. (2013). Phagocytic receptor signaling regulates clathrin and epsin-mediated cytoskeletal remodeling during apoptotic cell engulfment in C. elegans. DEVELOPMENT, 140 (15), 3230-3243. doi:10.1242/dev.093732
Vincelli, A. J., Pottinger, D. S., Zhong, F., Hanske, J., Rolland, S. G., Conradt, B., & Pletneva, E. V. (2013). Recombinant Expression, Biophysical Characterization, and Cardiolipin-Induced Changes of Two Caenorhabditis elegans Cytochrome c Proteins. BIOCHEMISTRY, 52 (4), 653-666. doi:10.1021/bi3014938
Vincelli, A. J., Pottinger, D. S., Rolland, S., Conradt, B., & Pletneva, E. V. (2012). Biophysical characterization of Caenorhabditis elegans cytochromes. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 243. AMER CHEMICAL SOC.
Lu, Y., Rolland, S. G., & Conradt, B. (2011). A molecular switch that governs mitochondrial fusion and fission mediated by the BCL2-like protein CED-9 of Caenorhabditis elegans. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108 (41), E813-E822. doi:10.1073/pnas.1103218108
Abdelwahid, E., Rolland, S., Teng, X., Conradt, B., Hardwick, J. M., & White, K. (2011). Mitochondrial involvement in cell death of non-mammalian eukaryotes. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1813 (4), 597-607. doi:10.1016/j.bbamcr.2010.10.008
Conradt, B., & Hatzold, J. (2010). Control of apoptosis during animal development by asymmetric cell division. EUROPEAN JOURNAL OF CELL BIOLOGY, 89, 59. ELSEVIER GMBH, URBAN & FISCHER VERLAG.
Rolland, S. G., & Conradt, B. (2010). New role of the BCL2 family of proteins in the regulation of mitochondrial dynamics. CURRENT OPINION IN CELL BIOLOGY, 22 (6), 852-858. doi:10.1016/j.ceb.2010.07.014
Nehme, R., Grote, P., Tomasi, T., Loeser, S., Holzkamp, H., Schnabel, R., & Conradt, B. (2010). Transcriptional upregulation of both egl-1 BH3-only and ced-3 caspase is required for the death of the male-specific CEM neurons. CELL DEATH AND DIFFERENTIATION, 17 (8), 1266-1276. doi:10.1038/cdd.2010.3
Kemp, B. J., Church, D. L., Hatzold, J., Conradt, B., & Lambie, E. J. (2009). gem-1 Encodes an SLC16 Monocarboxylate Transporter-Related Protein That Functions in Parallel to the gon-2 TRPM Channel During Gonad Development in Caenorhabditis elegans. GENETICS, 181 (2), 581-591. doi:10.1534/genetics.108.094870
Conradt, B. (2009). Genetic Control of Programmed Cell Death During Animal Development. ANNUAL REVIEW OF GENETICS, 43, 493-523. doi:10.1146/annurev.genet.42.110807.091533
Rolland, S. G., Lu, Y., David, C. N., & Conradt, B. (2009). The BCL-2-like protein CED-9 of C. elegans promotes FZO-1/Mfn1,2-and EAT-3/Opa1-dependent mitochondrial fusion. JOURNAL OF CELL BIOLOGY, 186 (4), 525-540. doi:10.1083/jcb.200905070
Reece-Hoyes, J. S., Deplancke, B., Barrasa, M. I., Hatzold, J., Smit, R. B., Arda, H. E., . . . Walhout, A. J. M. (2009). The C-elegans Snail homolog CES-1 can activate gene expression in vivo and share targets with bHLH transcription factors. NUCLEIC ACIDS RESEARCH, 37 (11), 3689-3698. doi:10.1093/nar/gkp232
Nilsson, L., Conradt, B., Ruaud, A. -. F., Chen, C. C. -. H., Hatzold, J., Bessereau, J. -. L., . . . Tuck, S. (2008). Caenorhabditis elegans num-1 negatively regulates endocytic recycling. GENETICS, 179 (1), 375-387. doi:10.1534/genetics.108.087247
Hatzold, J., & Conradt, B. (2008). Control of apoptosis by asymmetric cell division. PLOS BIOLOGY, 6 (4), 771-784. doi:10.1371/journal.pbio.0060084
Nehme, R., & Conradt, B. (2008). egl-1: a key activator of apoptotic cell death in C-elegans. ONCOGENE, 27, S30-S40. doi:10.1038/onc.2009.41
Doonan, R., Hatzold, J., Raut, S., Conradt, B., & Alfonso, A. (2008). HLH-3 is a C. elegans Achaete/Scute protein required for differentiation of the hermaphrodite-specific motor neurons. MECHANISMS OF DEVELOPMENT, 125 (9-10), 883-893. doi:10.1016/j.mod.2008.06.002
Ow, M. C., Martinez, N. J., Olsen, P. H., Silverman, H. S., Barrasa, M. I., Conradt, B., . . . Ambros, V. (2008). The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C-elegans. GENES & DEVELOPMENT, 22 (18), 2520-2534. doi:10.1101/gad.1678808
Schertel, C., & Conradt, B. (2007). C-elegans orthologs of components of the RB tumor suppressor complex have distinct pro-apoptotic functions. DEVELOPMENT, 134 (20), 3691-3701. doi:10.1242/dev.004606
Conradt, B. (2006). Cell biology – Mitochondria shape up. NATURE, 443 (7112), 646-647. doi:10.1038/443646a
Yu, X., Vought, V. E., Conradt, B., & Maine, E. M. (2006). Eukaryotic translation initiation factor 5B activity regulates larval growth rate and germline development in Caenorhabditis elegans. GENESIS, 44 (9), 412-418. doi:10.1002/dvg.20232
Grote, P., & Conradt, B. (2006). The PLZF-like protein TRA-4 cooperates with the Gli-like transcription factor TRA-1 to promote female development in C-elegans. DEVELOPMENTAL CELL, 11 (4), 561-573. doi:10.1016/j.devcel.2006.07.015
Rolland, S., & Conradt, B. (2006). The role of mitochondria in apoptosis induction in Caenorhabditis elegans: more than just innocent bystanders?. CELL DEATH AND DIFFERENTIATION, 13 (8), 1281-1286. doi:10.1038/sj.cdd.4401980
Schumacher, B., Schertel, C., Wittenburg, N., Tuck, S., Mitani, S., Gartner, A., . . . Shaham, S. (2005). C-elegans ced-13 can promote apoptosis and is induced in response to DNA damage. CELL DEATH AND DIFFERENTIATION, 12 (2), 153-161. doi:10.1038/sj.cdd.4401539
Schumacher, B., Schertel, C., Wittenburg, N., Tuck, S., Mitani, S., Gartner, A., . . . Shaham, S. (2005). C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage (vol 12, pg 153, 2005). CELL DEATH AND DIFFERENTIATION, 12 (5), 532. doi:10.1038/sj.cdd.4401605
Jagasia, R., Grote, P., Westermann, B., & Conradt, B. (2005). DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C-elegans. NATURE, 433 (7027), 754-760. doi:10.1038/nature03316
Conradt, B., & Xue, D. (2005). Programmed cell death. WormBook : the online review of C. elegans biology, 1-13. doi:10.1895/wormbook.1.32.1
Hoeppner, D. J., Spector, M. S., Ratliff, T. M., Kinchen, J. M., Granat, S., Lin, S. C., . . . Hengartner, M. O. (2004). eor-1 and eor-2 are required for cell-specific apoptotic death in C-elegans. DEVELOPMENTAL BIOLOGY, 274 (1), 125-138. doi:10.1016/j.ydbio.2004.06.022
Jager, S., Schwartz, H. T., Horvitz, H. R., & Conradt, B. (2004). The Caenorhabditis elegans F-box orotein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101 (34), 12549-12554. doi:10.1073/pnas.0405087101
Schumacher, B., Alpi, A., Wittenburg, N., Boulton, S., Hofmann, K., Saham, S., . . . Gartner, A. (2003). The roads to death, DNA damage induced apoptosis in the C. elegans germline. EUROPEAN JOURNAL OF CELL BIOLOGY, 82, 56. ELSEVIER GMBH.
Thellmann, M., Hatzold, J., & Conradt, B. (2003). The Snail-like CES-1 protein of C-elegans can block the expression of the BH3-only cell-death activator gene egl-1 by antagonizing the function of bHLH proteins. DEVELOPMENT, 130 (17), 4057-4071. doi:10.1242/dev.00597
Conradt, B. (2002). With a little help from your friends: cells don’t die alone. NATURE CELL BIOLOGY, 4 (6), E139-E143. doi:10.1038/ncb0602-e139
Conradt, B. (2001). Cell engulfment, no sooner ced than done. DEVELOPMENTAL CELL, 1 (4), 445-447. doi:10.1016/S1534-5807(01)00065-X
Conradt, B. (2000). Programmed cell death and its regulation and initiation in C. elegans. OF FISH, FLY, WORM, AND MAN, 29, 35-55. SPRINGER-VERLAG BERLIN.
Chen, F. L., Hersh, B. M., Conradt, B., Zhou, Z., Riemer, D., Gruenbaum, Y., & Horvitz, H. R. (2000). Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death. SCIENCE, 287 (5457), 1485-1489. doi:10.1126/science.287.5457.1485
Conradt, B., & Horvitz, H. R. (1999). The TRA-1A sex determination protein of C. elegans regulates sexually dimorphic cell deaths by repressing the egl-1 cell death activator gene. CELL, 98 (3), 317-327. doi:10.1016/S0092-8674(00)81961-3
Conradt, B., & Horvitz, H. R. (1998). The C-elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9. CELL, 93 (4), 519-529. doi:10.1016/S0092-8674(00)81182-4
Nicolson, T., Conradt, B., & Wickner, W. (1996). A truncated form of the Pho80 cyclin of Saccharomyces cerevisiae induces expression of a small cytosolic factor which inhibits vacuole inheritance. JOURNAL OF BACTERIOLOGY, 178 (14), 4047-4051. doi:10.1128/jb.178.14.4047-4051.1996
CONRADT, B., HAAS, A., & WICKNER, W. (1994). DETERMINATION OF 4 BIOCHEMICALLY DISTINCT, SEQUENTIAL STAGES DURING VACUOLE INHERITANCE IN-VITRO. JOURNAL OF CELL BIOLOGY, 126 (1), 99-110. doi:10.1083/jcb.126.1.99
HAAS, A., CONRADT, B., & WICKNER, W. (1994). G-PROTEIN LIGANDS INHIBIT IN-VITRO REACTIONS OF VACUOLE INHERITANCE. JOURNAL OF CELL BIOLOGY, 126 (1), 87-97. doi:10.1083/jcb.126.1.87
CONRADT, B., SHAW, J., VIDA, T., EMR, S., & WICKNER, W. (1992). INVITRO REACTIONS OF VACUOLE INHERITANCE IN SACCHAROMYCES-CEREVISIAE. JOURNAL OF CELL BIOLOGY, 119 (6), 1469-1479. doi:10.1083/jcb.119.6.1469
Wei, H., Lambie, E. J., Osório, D. S., Carvalho, A. X., & Conradt, B. (n.d.). PIG-1 MELK-dependent phosphorylation of nonmuscle myosin II promotes apoptosis through CES-1 Snail partitioning. Cold Spring Harbor Laboratory. doi:10.1101/2020.06.04.133983