The Conradt and Lambie Lab

• Sethi, A., Wei, H., Mishra, N., Segos, I., Lambie, E. J., Zanin, E., & Conradt, B. (2022). A caspase-RhoGEF axis contributes to the cell size threshold for apoptotic death in developing Caenorhabditis elegans. PLoS Biology, 20 (10), e3001786. doi:10.1371/journal.pbio.3001786
• Rolland, S., & Conradt, B. (2022). Genetic screen identifies non-mitochondrial proteins involved in the maintenance of mitochondrial homeostasis. microPublication Biology. doi:10.17912/micropub.biology.000562
• Haeussler, S., & Conradt, B. (2022). Methods to Study the Mitochondrial Unfolded Protein Response (UPRmt) in Caenorhabditis elegans. Methods in Molecular Biology, 2378, 249-259. doi:10.1007/978-1-0716-1732-8_16
• Haeussler, S., Yeroslaviz, A., Rolland, S. G., Luehr, S., Lambie, E. J., & Conradt, B. (2021). Genome-wide RNAi screen for regulators of UPRmt in Caenorhabditis elegans mutants with defects in mitochondrial fusion. G3 (Bethesda). doi:10.1093/g3journal/jkab095
• Haeussler, S., Köhler, F., Witting, M., Premm, M. F., Rolland, S. G., Fischer, C., . . . Conradt, B. (2020). Autophagy compensates for defects in mitochondrial dynamics. PLoS Genet, 16 (3), e1008638. doi:10.1371/journal.pgen.1008638
• Fischer, C. A., Besora-Casals, L., Rolland, S. G., Haeussler, S., Singh, K., Duchen, M., . . . Marr, C. (2020). MitoSegNet: Easy-to-use Deep Learning Segmentation for Analyzing Mitochondrial Morphology. iScience, 23 (10). doi:10.1016/j.isci.2020.101601
• Basch, M., Wagner, M., Rolland, S., Carbonell, A., Zeng, R., Khosravi, S., . . . Wagener, N. (2020). Msp1 cooperates with the proteasome for extraction of arrested mitochondrial import intermediates. Molecular biology of the cell, 31 (8), 753-767. doi:10.1091/mbc.E19-06-0329
• Wei, H., Lambie, E. J., Osório, D. S., Carvalho, A. X., & Conradt, B. (2020). PIG-1 MELK-dependent phosphorylation of nonmuscle myosin II promotes apoptosis through CES-1 Snail partitioning. PLoS Genet, 16 (9), e1008912. doi:10.1371/journal.pgen.1008912
• Deng, W., Bates, J. A., Wei, H., Bartoschek, M. D., Conradt, B., & Leonhardt, H. (2020). Tunable light and drug induced depletion of target proteins. Nature Communications, 11 (1). doi:10.1038/s41467-019-14160-8
• Rolland, S. G., Schneid, S., Schwarz, M., Rackles, E., Fischer, C., Haeussler, S., . . . Conradt, B. (2019). Compromised Mitochondrial Protein Import Acts as a Signal for UPRmt. Cell Reports. doi:10.1016/j.celrep.2019.07.049
• Wei, H., Yan, B., Gagneur, J., & Conradt, B. (2019). Corrigendum: Caenorhabditis elegans CES-1 Snail Represses pig-1 MELK Expression To Control Asymmetric Cell Division. Genetics, 211 (2), 787. doi:10.1534/genetics.118.301849
• Wagner, A., Hofmeister, O., Rolland, S. G., Maiser, A., Aasumets, K., Schmitt, S., . . . Wolf, A. (2019). Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans. Journal of Cell Science, 132 (19). doi:10.1242/jcs.223891
• Erpf, A. C., Stenzel, L., Memar, N., Antoniolli, M., Osepashvili, M., Schnabel, R., . . . Mikeladze-Dvali, T. (2019). PCMD-1 Organizes Centrosome Matrix Assembly in C. elegans. Current Biology, 29 (8), 1324-1336.e6. doi:10.1016/j.cub.2019.03.029
• Conradt, B. (2019). The Power of C. elegans: A Tribute to Sydney Brenner – A Spirit of Innovation. DEVELOPMENTAL CELL, 49 (4), 496. doi:10.1016/j.devcel.2019.05.009
• Memar, N., Schiemann, S., Hennig, C., Findeis, D., Conradt, B., & Schnabel, R. (2019). Twenty million years of evolution: The embryogenesis of four Caenorhabditis species are indistinguishable despite extensive genome divergence. Developmental Biology. doi:10.1016/j.ydbio.2018.12.022
• Mishra, N., Wei, H., & Conradt, B. (2018). Caenorhabditis elegans ced-3 Caspase Is Required for Asymmetric Divisions That Generate Cells Programmed To Die. GENETICS, 210 (3), 983-998. doi:10.1534/genetics.118.301500
• Zielich, J., Tzima, E., Schröder, E. A., Jemel, F., Conradt, B., & Lambie, E. J. (2018). Overlapping expression patterns and functions of three paralogous P5B ATPases in Caenorhabditis elegans. PLoS ONE, 13 (3), e0194451. doi:10.1371/journal.pone.0194451
• Wei, H., Yan, B., Gagneur, J., & Conradt, B. (2017). Caenorhabditis elegans CES-1 Snail Represses pig-1 MELK Expression To Control Asymmetric Cell Division. GENETICS, 206 (4), 2069-2084. doi:10.1534/genetics.117.202754
• Sherrard, R., Luehr, S., Holzkamp, H., McJunkin, K., Memar, N., & Conradt, B. (2017). miRNAs cooperate in apoptosis regulation during C. elegans development. GENES & DEVELOPMENT, 31 (2), 209-222. doi:10.1101/gad.288555.116
• Conradt, B. (2017). Partners in Crime. DEVELOPMENTAL CELL, 41 (6), 573-574. doi:10.1016/j.devcel.2017.06.002
• Lambie, E. J., & Conradt, B. (2016). Deadly dowry: how engulfment pathways promote cell killing. CELL DEATH AND DIFFERENTIATION, 23 (4), 553-554. doi:10.1038/cdd.2015.170
• Conradt, B., Wu, Y. -. C., & Xue, D. (2016). Programmed Cell Death During Caenorhabditis elegans Development. GENETICS, 203 (4), 1533-1562. doi:10.1534/genetics.115.186247
• Chakraborty, S., Lambie, E. J., Bindu, S., Mikeladze-Dvali, T., & Conradt, B. (2015). Engulfment pathways promote programmed cell death by enhancing the unequal segregation of apoptotic potential. NATURE COMMUNICATIONS, 6, ARTN 10126. doi:10.1038/ncomms10126
• Koehler, F., Mueller-Rischart, A. K., Conradt, B., & Rolland, S. G. (2015). The loss of LRPPRC function induces the mitochondrial unfolded protein response. AGING-US, 7 (9), 701-717.
• Roy, S. H., Tobin, D. V., Memar, N., Beltz, E., Holmen, J., Clayton, J. E., . . . Saito, R. M. (2014). A Complex Regulatory Network Coordinating Cell Cycles During C. elegans Development Is Revealed by a Genome-Wide RNAi Screen. G3-GENES GENOMES GENETICS, 4 (5), 795-804. doi:10.1534/g3.114.010546
• Regmi, S. G., Rolland, S. G., & Conradt, B. (2014). Age-dependent changes in mitochondrial morphology and volume are not predictors of lifespan. AGING-US, 6 (2), 118-130. doi:10.18632/aging.100639
• Ye, A. L., Ragle, J. M., Conradt, B., & Bhalla, N. (2014). Differential Regulation of Germline Apoptosis in Response to Meiotic Checkpoint Activation. GENETICS, 198 (3), 995-1000. doi:10.1534/genetics.114.170241
• Zanin, E., Desai, A., Poser, I., Toyoda, Y., Andree, C., Moebius, C., . . . Oegema, K. (2013). A Conserved RhoGAP Limits M Phase Contractility and Coordinates with Microtubule Asters to Confine RhoA during Cytokinesis. DEVELOPMENTAL CELL, 26 (5), 496-510. doi:10.1016/j.devcel.2013.08.005
• Lambie, E. J., Tieu, P. J., Lebedeva, N., Church, D. L., & Conradt, B. (2013). CATP-6, a C. elegans Ortholog of ATP13A2 PARK9, Positively Regulates GEM-1, an SLC16A Transporter. PLOS ONE, 8 (10), ARTN e77202. doi:10.1371/journal.pone.0077202
• Yan, B., Memar, N., Gallinger, J., & Conradt, B. (2013). Coordination of Cell Proliferation and Cell Fate Determination by CES-1 Snail. PLOS GENETICS, 9 (10), ARTN e1003884. doi:10.1371/journal.pgen.1003884
• Rolland, S. G., Motori, E., Memar, N., Hench, J., Frank, S., Winklhofer, K. F., & Conradt, B. (2013). Impaired complex IV activity in response to loss of LRPPRC function can be compensated by mitochondrial hyperfusion. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110 (32), E2967-E2976. doi:10.1073/pnas.1303872110
• Shen, Q., He, B., Lu, N., Conradt, B., Grant, B. D., & Zhou, Z. (2013). Phagocytic receptor signaling regulates clathrin and epsin-mediated cytoskeletal remodeling during apoptotic cell engulfment in C. elegans. DEVELOPMENT, 140 (15), 3230-3243. doi:10.1242/dev.093732
• Vincelli, A. J., Pottinger, D. S., Zhong, F., Hanske, J., Rolland, S. G., Conradt, B., & Pletneva, E. V. (2013). Recombinant Expression, Biophysical Characterization, and Cardiolipin-Induced Changes of Two Caenorhabditis elegans Cytochrome c Proteins. BIOCHEMISTRY, 52 (4), 653-666. doi:10.1021/bi3014938
• Vincelli, A. J., Pottinger, D. S., Rolland, S., Conradt, B., & Pletneva, E. V. (2012). Biophysical characterization of Caenorhabditis elegans cytochromes. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 243. AMER CHEMICAL SOC.
• Lu, Y., Rolland, S. G., & Conradt, B. (2011). A molecular switch that governs mitochondrial fusion and fission mediated by the BCL2-like protein CED-9 of Caenorhabditis elegans. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108 (41), E813-E822. doi:10.1073/pnas.1103218108
• Abdelwahid, E., Rolland, S., Teng, X., Conradt, B., Hardwick, J. M., & White, K. (2011). Mitochondrial involvement in cell death of non-mammalian eukaryotes. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1813 (4), 597-607. doi:10.1016/j.bbamcr.2010.10.008
• Conradt, B., & Hatzold, J. (2010). Control of apoptosis during animal development by asymmetric cell division. EUROPEAN JOURNAL OF CELL BIOLOGY, 89, 59. ELSEVIER GMBH, URBAN & FISCHER VERLAG.
• Rolland, S. G., & Conradt, B. (2010). New role of the BCL2 family of proteins in the regulation of mitochondrial dynamics. CURRENT OPINION IN CELL BIOLOGY, 22 (6), 852-858. doi:10.1016/j.ceb.2010.07.014
• Nehme, R., Grote, P., Tomasi, T., Loeser, S., Holzkamp, H., Schnabel, R., & Conradt, B. (2010). Transcriptional upregulation of both egl-1 BH3-only and ced-3 caspase is required for the death of the male-specific CEM neurons. CELL DEATH AND DIFFERENTIATION, 17 (8), 1266-1276. doi:10.1038/cdd.2010.3
• Kemp, B. J., Church, D. L., Hatzold, J., Conradt, B., & Lambie, E. J. (2009). gem-1 Encodes an SLC16 Monocarboxylate Transporter-Related Protein That Functions in Parallel to the gon-2 TRPM Channel During Gonad Development in Caenorhabditis elegans. GENETICS, 181 (2), 581-591. doi:10.1534/genetics.108.094870
• Conradt, B. (2009). Genetic Control of Programmed Cell Death During Animal Development. ANNUAL REVIEW OF GENETICS, 43, 493-523. doi:10.1146/annurev.genet.42.110807.091533
• Rolland, S. G., Lu, Y., David, C. N., & Conradt, B. (2009). The BCL-2-like protein CED-9 of C. elegans promotes FZO-1/Mfn1,2-and EAT-3/Opa1-dependent mitochondrial fusion. JOURNAL OF CELL BIOLOGY, 186 (4), 525-540. doi:10.1083/jcb.200905070
• Reece-Hoyes, J. S., Deplancke, B., Barrasa, M. I., Hatzold, J., Smit, R. B., Arda, H. E., . . . Walhout, A. J. M. (2009). The C-elegans Snail homolog CES-1 can activate gene expression in vivo and share targets with bHLH transcription factors. NUCLEIC ACIDS RESEARCH, 37 (11), 3689-3698. doi:10.1093/nar/gkp232
• Nilsson, L., Conradt, B., Ruaud, A. -. F., Chen, C. C. -. H., Hatzold, J., Bessereau, J. -. L., . . . Tuck, S. (2008). Caenorhabditis elegans num-1 negatively regulates endocytic recycling. GENETICS, 179 (1), 375-387. doi:10.1534/genetics.108.087247
• Hatzold, J., & Conradt, B. (2008). Control of apoptosis by asymmetric cell division. PLOS BIOLOGY, 6 (4), 771-784. doi:10.1371/journal.pbio.0060084
• Nehme, R., & Conradt, B. (2008). egl-1: a key activator of apoptotic cell death in C-elegans. ONCOGENE, 27, S30-S40. doi:10.1038/onc.2009.41
• Doonan, R., Hatzold, J., Raut, S., Conradt, B., & Alfonso, A. (2008). HLH-3 is a C. elegans Achaete/Scute protein required for differentiation of the hermaphrodite-specific motor neurons. MECHANISMS OF DEVELOPMENT, 125 (9-10), 883-893. doi:10.1016/j.mod.2008.06.002
• Ow, M. C., Martinez, N. J., Olsen, P. H., Silverman, H. S., Barrasa, M. I., Conradt, B., . . . Ambros, V. (2008). The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C-elegans. GENES & DEVELOPMENT, 22 (18), 2520-2534. doi:10.1101/gad.1678808
• Schertel, C., & Conradt, B. (2007). C-elegans orthologs of components of the RB tumor suppressor complex have distinct pro-apoptotic functions. DEVELOPMENT, 134 (20), 3691-3701. doi:10.1242/dev.004606
• Conradt, B. (2006). Cell biology – Mitochondria shape up. NATURE, 443 (7112), 646-647. doi:10.1038/443646a
• Yu, X., Vought, V. E., Conradt, B., & Maine, E. M. (2006). Eukaryotic translation initiation factor 5B activity regulates larval growth rate and germline development in Caenorhabditis elegans. GENESIS, 44 (9), 412-418. doi:10.1002/dvg.20232
• Grote, P., & Conradt, B. (2006). The PLZF-like protein TRA-4 cooperates with the Gli-like transcription factor TRA-1 to promote female development in C-elegans. DEVELOPMENTAL CELL, 11 (4), 561-573. doi:10.1016/j.devcel.2006.07.015
• Rolland, S., & Conradt, B. (2006). The role of mitochondria in apoptosis induction in Caenorhabditis elegans: more than just innocent bystanders?. CELL DEATH AND DIFFERENTIATION, 13 (8), 1281-1286. doi:10.1038/sj.cdd.4401980
• Schumacher, B., Schertel, C., Wittenburg, N., Tuck, S., Mitani, S., Gartner, A., . . . Shaham, S. (2005). C-elegans ced-13 can promote apoptosis and is induced in response to DNA damage. CELL DEATH AND DIFFERENTIATION, 12 (2), 153-161. doi:10.1038/sj.cdd.4401539
• Schumacher, B., Schertel, C., Wittenburg, N., Tuck, S., Mitani, S., Gartner, A., . . . Shaham, S. (2005). C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage (vol 12, pg 153, 2005). CELL DEATH AND DIFFERENTIATION, 12 (5), 532. doi:10.1038/sj.cdd.4401605
• Jagasia, R., Grote, P., Westermann, B., & Conradt, B. (2005). DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C-elegans. NATURE, 433 (7027), 754-760. doi:10.1038/nature03316
• Conradt, B., & Xue, D. (2005). Programmed cell death. WormBook : the online review of C. elegans biology, 1-13. doi:10.1895/wormbook.1.32.1
• Hoeppner, D. J., Spector, M. S., Ratliff, T. M., Kinchen, J. M., Granat, S., Lin, S. C., . . . Hengartner, M. O. (2004). eor-1 and eor-2 are required for cell-specific apoptotic death in C-elegans. DEVELOPMENTAL BIOLOGY, 274 (1), 125-138. doi:10.1016/j.ydbio.2004.06.022
• Jager, S., Schwartz, H. T., Horvitz, H. R., & Conradt, B. (2004). The Caenorhabditis elegans F-box orotein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101 (34), 12549-12554. doi:10.1073/pnas.0405087101
• Schumacher, B., Alpi, A., Wittenburg, N., Boulton, S., Hofmann, K., Saham, S., . . . Gartner, A. (2003). The roads to death, DNA damage induced apoptosis in the C. elegans germline. EUROPEAN JOURNAL OF CELL BIOLOGY, 82, 56. ELSEVIER GMBH.
• Thellmann, M., Hatzold, J., & Conradt, B. (2003). The Snail-like CES-1 protein of C-elegans can block the expression of the BH3-only cell-death activator gene egl-1 by antagonizing the function of bHLH proteins. DEVELOPMENT, 130 (17), 4057-4071. doi:10.1242/dev.00597
• Conradt, B. (2002). With a little help from your friends: cells don’t die alone. NATURE CELL BIOLOGY, 4 (6), E139-E143. doi:10.1038/ncb0602-e139
• Conradt, B. (2001). Cell engulfment, no sooner ced than done. DEVELOPMENTAL CELL, 1 (4), 445-447. doi:10.1016/S1534-5807(01)00065-X
• Conradt, B. (2000). Programmed cell death and its regulation and initiation in C. elegans. OF FISH, FLY, WORM, AND MAN, 29, 35-55. SPRINGER-VERLAG BERLIN.
• Chen, F. L., Hersh, B. M., Conradt, B., Zhou, Z., Riemer, D., Gruenbaum, Y., & Horvitz, H. R. (2000). Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death. SCIENCE, 287 (5457), 1485-1489. doi:10.1126/science.287.5457.1485
• Conradt, B., & Horvitz, H. R. (1999). The TRA-1A sex determination protein of C. elegans regulates sexually dimorphic cell deaths by repressing the egl-1 cell death activator gene. CELL, 98 (3), 317-327. doi:10.1016/S0092-8674(00)81961-3
• Conradt, B., & Horvitz, H. R. (1998). The C-elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9. CELL, 93 (4), 519-529. doi:10.1016/S0092-8674(00)81182-4
• Nicolson, T., Conradt, B., & Wickner, W. (1996). A truncated form of the Pho80 cyclin of Saccharomyces cerevisiae induces expression of a small cytosolic factor which inhibits vacuole inheritance. JOURNAL OF BACTERIOLOGY, 178 (14), 4047-4051. doi:10.1128/jb.178.14.4047-4051.1996
• CONRADT, B., HAAS, A., & WICKNER, W. (1994). DETERMINATION OF 4 BIOCHEMICALLY DISTINCT, SEQUENTIAL STAGES DURING VACUOLE INHERITANCE IN-VITRO. JOURNAL OF CELL BIOLOGY, 126 (1), 99-110. doi:10.1083/jcb.126.1.99
• HAAS, A., CONRADT, B., & WICKNER, W. (1994). G-PROTEIN LIGANDS INHIBIT IN-VITRO REACTIONS OF VACUOLE INHERITANCE. JOURNAL OF CELL BIOLOGY, 126 (1), 87-97. doi:10.1083/jcb.126.1.87
• CONRADT, B., SHAW, J., VIDA, T., EMR, S., & WICKNER, W. (1992). INVITRO REACTIONS OF VACUOLE INHERITANCE IN SACCHAROMYCES-CEREVISIAE. JOURNAL OF CELL BIOLOGY, 119 (6), 1469-1479. doi:10.1083/jcb.119.6.1469
• Wei, H., Lambie, E. J., Osório, D. S., Carvalho, A. X., & Conradt, B. (n.d.). PIG-1 MELK-dependent phosphorylation of nonmuscle myosin II promotes apoptosis through CES-1 Snail partitioning. Cold Spring Harbor Laboratory. doi:10.1101/2020.06.04.133983